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There remain a number of important unanswered questions regarding whether the observed biological effects of AngIV and its analogs are mediated by the HGF/c-Met system

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For example, peptides like MK-677 Ibutamoren stimulate growth hormone secretion, which supports muscle growth, enhances fat breakdown, and improves overall metabolic function

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Reduced energy expenditure, linked to lower lipid oxidation, appears to be an early change, supported by animal studies showing that oophorectomy lowers energy expenditure independent of calorie intake [135]