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Key considerations in UK practice include: Cancer cure status TRT is generally only considered after curative treatment with no evidence of disease recurrence Time since treatment Expert opinion typically suggests waiting at least 1224 months post-treatment before considering TRT [5] [11] Prostate-specific antigen (PSA) levels Stable, undetectable or very low PSA levels are typically required (measured in g/L in the UK) Cancer characteristics Low-risk, organ-confined disease with favourable pathology is preferred The European Association of Urology (EAU) guidelines, which influence UK practice, state that TRT may be considered in selected patients with low-risk prostate cancer who have been successfully treated, though they emphasise the need for careful patient selection and monitoring

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