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10.1016/j.pharmthera.2007.03.002 35 BogerR

[10] The hormone also activates membrane-associated G-protein-coupled estrogen receptor (GPER), triggering second-messenger cascades that rapidly augment nitric oxide release, influence intracellular calcium, and provide neuroprotective signals independent of gene transcription

In a healthy body, mast cells only release these mediators in response to genuine threats, like parasites or severe allergens

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