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Short-term, the safety profile is favorable
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Understanding the complex epigenetic regulation of neuronal activity and adult neurogenesis is integral to designing therapeutic approaches to restore neurogenesis and cognitive functions
It is characterized by rapid neuronal death and extracellular matrix degradation post-injury, culminating in cavity formation and long-term neurological deficits (217, 218)
Increasing research efforts have focused on stroke-induced changes in remotely connected regions, including cortical areas in the contralesional hemisphere, thalamus, and the cerebellum, since stroke can disrupt neuronal function within minutes and extend this effect to connected areas [88, 89]
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