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Key Insight: With no energy improvements by week 4, bloodwork can help assess whether NNMT is being effectively inhibited
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Neural Tube Defects Deficiency in early pregnancy increases the risk of brain and spinal cord malformations, especially when combined with low folate [*]
The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained
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