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At the cellular level in the brain abnormalities are discernible years before the disease becomes clinically manifest, but these can only be visualized microscopically following biopsy

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Ethics declarations Competing interests The authors declare no competing financial interests

In addition, GLP-1RAs bind to GLP-1 receptors, activating the Akt signaling pathway, which subsequently enhances intracellular Wnt signal transduction [99]

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