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They are naturally occurring in the body and typically have fewer side effects compared to pharmaceuticals, as they are designed to target specific biological functions

Furthermore, a wrong open biopsy or nononcological surgical procedure may lead to possible contamination and ultimately a more radical procedure than would have originally been necessary, where this can be prevented by an early referral to a highly specialized sarcoma center

In addition, the GO analysis of genes enriched in terms of molecular function showed a prominent abundance of gene signatures associated with cytokine binding and C-X-C chemokine binding ( Figure 2C )

Statistical Analysis Dichotomous outcomes were analyzed by risk ratios (RRs) and 95% confidence intervals (CIs) using the DerSimonian and Laird random-effects model

Because of the defined role of GST in drug metabolism, elevated expression of GSTP1 in solid tumors or in drug-resistant cells has been associated frequently with detoxification reactions even in instances where there is no evidence that the selecting drug is a substrate for GSTP1