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A 15% body weight reduction the STEP-1 semaglutide benchmark is associated with type 2 diabetes remission in 37% of treated patients, 28% reduction in hypertension medication requirements, 25% improvement in sleep apnea severity, and MASH progression reversal

This is particularly connected to newer combined GLP-1-GIP medication tirzepatide (Zepbound), which may reduce the absorption of oral contraceptives into the system

This allows providers to see what type of weight a patient is losing, making sure progress comes primarily from fat, not muscle

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