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Benefits of the maintenance approach include sustained appetite regulation, continued metabolic support, fewer side effects at lower doses, and easier dose escalation if weight begins to creep

Persistent hyperglycemia and metabolic dysregulation promote oxidative stress, reduce nitric oxide bioavailability, and activate inflammatory pathways, thereby accelerating atherosclerosis and cardiovascular complications

Warkad MS, Kim CH, Kang BG, Park SH, Jung JS, Feng JH, Inci G, Kim SC, Suh HW, Lim SS, Lee JY (2021) Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells