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The IRS1 and TRS1 genes from human cytomegalovirus (HCMV) have been inserted into HSV-2 to improve protein synthesis and replication by inhibiting PKR kinase activity and autophagy, thereby facilitating robust viral protein production and survival within tumor cells (81)

OGP was found to exert an anabolic effect on bone cells, resulting in an increase of bone formation and overall bone mass [81, 83]

However, in GCLM KO mice, genes encoding lipid synthesis enzymes, Fasn and Scd , were further down-regulated, whereas Fads1 was up-regulated by ethanol, the net effect of which would be expected to result in lower levels of total TG and increases in the relative abundance of certain lipid species

In another study, Rehman et al

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