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127129 Telomere attrition The gradual reduction of telomeres as we grow older is a significant characteristic of aging, leading to cellular senescence and impairing tissue function

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Typical criteria include: Documented diagnosis of type 2 diabetes with inadequate glycemic control on metformin or other first-line agents BMI 27 kg/m with weight-related comorbidity or BMI 30 kg/m (for weight management indications) Trial and failure of alternative therapies Absence of contraindications Coverage for weight management indications under commercial plans has expanded but remains inconsistent, with many employers specifically excluding obesity medications from pharmacy benefits