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Pharmacological Reviews October 2016, 68 (4) 954-1013

273 (4), G920G927 (1997)

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Indeed, there is evidence that the ability to synthesize VC without the intervention of GULO may have arisen independently multiple times in protostomian evolution, since this gene is absent in nematodes and insects, but present in Arachnida species that are closer to insects [19, 21]