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Succinate, a key intermediate metabolite of the TCA cycle in the mitochondrial matrix, accumulates under conditions such as intense physical exertion, ischemia-reperfusion, or poisoning, where the mitochondrial respiratory chain is inhibited

Although migraines are not typically classified as neurodegenerative diseases marked by extensive cell death, studies have reported the occurrence of apoptosis and pyroptosis, both forms of programmed cell death (Wang et al., 2022)

We also confirmed those results by using CD36-siRNA on SUM-159

On the test day, 7 consecutive trials of 2 min per trial (with 1-min intertrial intervals) were undertaken with the following set speeds: 12, 16, 20, 25, 30, 35, and 40 rpm

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