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GLP-1 receptor agonists first entered the market in 2005 with the approval of exenatide (Byetta) for type 2 diabetes

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22 Increasing renal glucose reabsorption in T1DM and T2DM seems counterproductive because it would rather maintain then fend off hyperglycemia

In addition, this specificity helps tether the enzyme tightly to the plasma membrane in order to access substrate through ionic interactions between the phosphate groups of PIP2 and charged residues in the PH domain