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Recent advances in imaging, including contrast-enhanced MRI with intrathecal gadolinium tracers, allow in vivo assessment of glymphatic clearance efficiency [420]

Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)

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If you are experiencing too much fatigue, your provider might suggest focusing more on NAD and nutrient support

8 Hyperglycemia and hyperlipidemia disrupt nerve function via multiple pathways, 9 including protein kinase C (PKC) pathway, polyol pathway, advanced glycosylated terminal (AGE) pathway, hexosamine pathway, PARP pathway, insulin pathway, compounded by mitochondrial dysfunction, oxidative stress, inflammatory response, metabolic abnormalities, and microvascular disease