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[18] [19] For individuals with a BMI of 30 kg/m or above or 27.5 kg/m and above for people from certain ethnic backgrounds at higher metabolic risk, in line with NICE guidance referral to a structured, tiered weight management programme may be appropriate

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For instance, regulatory T cells modulate neuroinflammation and microglial pyroptosis in LPC-induced demyelination via this pathway, thereby alleviating myelin loss and cognitive dysfunction (157)