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Commonly reported ones include gastrointestinal issues like nausea and diarrhea, typically present when starting or adjusting the dosage

How This Compares to Similar Drugs Tirzepatide's Phase 3 trials began in 2019, FDA submission happened in mid-2022, and approval came in May 2022 (for diabetes) and November 2023 (for obesity)

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The ENS communicates with the brain through neuropeptides such as substance P and vasoactive intestinal peptide, which are involved in modulating inflammatory responses (Marsilio, 2019)