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Honda et al., 1996

Although the pigmentary lesions might appear trivial and insignificant, proper identification of characteristic pigmentation and subsequent establishment of differential diagnoses can promote essential examination and evaluation, facilitate an early diagnosis of potential underlying diseases, guide a reasonable medical strategy, prevent unnecessary testing, and reduce mortality due to malignancies and severe complications

Dilara A

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Oxidative stress biomarkers As discussed above, oxidative stress is characterized by an imbalance between oxidants and antioxidants in favor of oxidants and may result in irreversible chemical modifications