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3 The levels of monoamine neurotransmitters (5-HT, NE, and DA) are insufficient in the synaptic cleft of MDD patients, correspondingly, the explored antidepressants such as tricyclic antidepressants(TCAs), SSRIs and SNRIs almostly act on the channels responsible for inhibiting reuptake of these neurotransmitters

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CDA-HFD animals were allocated to treatment groups without randomization

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The FDA has approved a number of peptides as medications, including insulin for diabetics who dont naturally produce it and human growth hormone for children with developmental disorders caused by low levels of the hormone