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However, several important considerations argue for caution in extending orforglipron to pediatric populations

Laraia BA, Adler NE, Coleman-Phox K, Vieten C, Mellin L, Kristeller JL, Thomas M, Stotland NE, Lustig RH , Dallman MF, Hecht FM, Bush NR, de Groat CL, Epel E

These are also the doses studied and approved for prevention of secondary cardiovascular events and metabolic dysfunction-associated steatotic liver disease (semaglutide) and for sleep apnea (tirzepatide)

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Copper Safety Concerns about copper toxicity from GHK-Cu are understandable but largely unwarranted at recommended doses