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Ding Y, Chen X, Liu C, Ge W, Wang Q, Hao X, et al

Understanding B12 treatments phases and how long it lasts helps doctors tailor therapy for each patient

It serves two clear functions it confers proteolytic resistance by disrupting normal protease recognition and cleavage at the D-amino acid bond, significantly extending the peptides biological half-life compared to an all-L-amino acid analogue, and it optimises the three-dimensional conformation of the peptide N-terminus for high-affinity binding to the mu-opioid receptor binding pocket

Neurology 66, 664671.10.1212/01.wnl.0000201252.57661.e1 187 ObataT