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The brain, sensing a drop in blood pressure and oxygen, initiates a "fight or flight" surge of adrenaline and norepinephrine, which causes the rapid, pounding heart rate (tachycardia), severe lightheadedness, and physical tremors associated with orthostatic intolerance

This window encompasses the initial dose and at least one dose increase

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It describes discussing alternative agents, a slower escalation plan, or a different administration route with a provider as a standard clinical approach rather than a failure of the medication

These include studies evaluating semaglutide and dulaglutide in individuals with AUD, with primary outcomes measuring changes in drinking patterns, craving intensity, and alcohol-related consequences