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In fact, many factors must be considered when analyzing the findings from observational studies that examine the association between diabetes therapies and cancer, for example sample size of the population examined, type and duration of diabetes, the level of metabolic control, comorbidities, and duration of follow-up

The prescription cascade, where new medications are added to treat the adverse effects of other medicationsfurther exacerbates the problem (9-10)

Various combinations of the defense mechanisms are tested in order to determine the ideal defense against oxidative stress in order to maximize the longevity in presence of heavy metals

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