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Worldwide, CVD is among the leading causes of morbidity and mortality and is reported to be one of the leading causes of hospitalization in Canada, alongside stroke

Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight

doi: 10.1016/j.metabol.2019.154045

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