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If standard endocrine therapy is failing, the most useful appointment question may be, "What mechanism of resistance are we treating, and is there a trial that matches it?" When to ask about clinical trials Ask early if: Your cancer progressed on endocrine therapy: That often signals a need for a different strategy, not just a different brand name

Conversations around the perceived collapse of body positivity in the era of Ozempic resurfaced repeatedly throughout January, March and May without any single triggering event, suggesting the topic has become a recurring structural feature of GLP-1 discourse on the platform

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