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Presented at the 18th International Diabetes Federation Congress

Emphasis will be placed on the metabolic pathways and relevant players (Table 1) that interfere with cysteine anabolism and catabolism, and the determinants that affect cysteine bioavailability, thereby influencing cancer development

For example, UA-induced cytokine expression is NF-B-mediated.[32] Regulation of glutathione peroxidase and GCL is also NF-B-dependent.[33] In our study, we established a very strong positive cor- relation between mRNA levels of GCLc, GS, and GR on the one hand, and between GR and GS on the other

When patients present with albuminuria, declining eGFR, cardiovascular disease, or inadequate HbA1c control despite lifestyle changes and metformin