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Merritt C, Rasoloson D, Ko D, Seydoux G

Management strategies include choosing more easily digestible proteins (fish, eggs, Greek yogurt), cutting meat into very small pieces, cooking proteins with moisture (braising, slow-cooking), and avoiding dry or tough preparations

Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation

The mechanism works regardless of starting body fat level, though individuals with BMIs above 40 may benefit from the full 12mg dose more than those in the 30-35 BMI range

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