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30 Furthermore, metabolic conditions such as iron deficiency can alter progenitor cell fate, favoring adipogenesis over osteogenesis, underscoring the sensitivity of these developmental processes to energetic signals

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This can result in: Facial hollowing or gauntness Loose or crepey skin on the face, neck, arms, abdomen, or thighs More visible wrinkles and skin texture changes Although the skin continues to remodel for months after weight stabilizes, many patients seek non-surgical options to support collagen production and restore a more youthful appearance