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Reduced glutathione (GSH) acts as peroxide scavenger and its oxidised form (GSSG) can be further reduced by glutathione reductase (GR) using NADPH as substrate [16]

Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, et al

Similar content being viewed by others Introduction Glutathione is a biologically active tripeptide composed of glutamic acid, cysteine, and glycine (Kobayashi et al., 2022)

Increasing antioxidant defense not only protects the brain, but it also helps detox harmful substances from the body

Nrf2 reduces ferroptosis by regulating the expression of genes related to iron metabolism and activating the expression of antioxidant enzymes in the cell [114]