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However, with increasing doses of acetaminophen, there is progressive dislocation of nuclear translocation, transcription, translation and protein activity as the rate of drug bioactivation over-whelms cell defence through the destruction of crit-ical proteins at least 31 of these critical proteins have been identified (Park et al ., 2005)

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Increased Binding of Low Density Lipoprotein to Liver Membranes from Rats Treated with 17 Alpha-Ethinyl Estradiol