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Prescribers seeking evidence-based guidance on the neuropsychiatric or affective side effect profile of GLP-1 receptor agonists, including semaglutide, should refer to the published regulatory safety communications from the FDA and EMA, the SUSTAIN and STEP trial data, and peer-reviewed pharmacovigilance literature examining anhedonia, mood changes, and related adverse events in this drug class

Del Saz, M.C.L

Yet it skews more heavily into biotechnology (2x the weight allocation versus THNR)

The step requirement can be waived with documented contraindication, intolerance, or insufficient response

Keep the habits that fit and let the stretchier ones go