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These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation [50]

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In the same trial, they also tested DAS (0, 223, 429, or 860 ppb) and found a similar dose relationship

Researchers have also explored possible clinical applications for conditions like erythropoietic protoporphyria, where increased melanin may reduce light sensitivity