LCMS analysis was carried out by the URMC Metabolomics Resource
and accordingly nerve damage appeared in various brain areas, with most prominent damage in corpus callosum, laterodorsal thalamus, nucleus reunions, anterior horn motor neurons, regional heterogeneities which suggest differences in the underlying pathophysiology as it had been previously claimed (72)
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Another study of the same group further demonstrated the cytotoxic in vitro effect of gemigliptin in TC cells also showing an increase in its cytotoxic activity when combined with one histone deacetylase inhibitor (PXD101) (Kim et al., 2018b)