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Endogenous expression of ODN-related peptides in astrocytes contributes to cell protection against oxidative stress: astrocyte-neuron crosstalk relevance for neuronal survival

This limitation is shared by most unmodified peptides and is why pharmaceutical peptide drugs require extensive chemical modification or alternative delivery routes

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459,460 Neural stimulation has been reported to modify cortical excitability by affecting GABAergic function and causing LTP or LTD-like excitatory synaptic strength