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Furthermore, too much ROS inside cells can harm proteins, lipids, and DNA
PMID: Summary Keywords GLP-1 receptor (GLP-1R), metabolic dysfunction, Mitochondria-ER Contact Sites (MERCS), signalosomes, GLP1 receptor agonist (GLP1-RAs) Citation Cruz P, Puebla-Huerta A, Troncoso MF, Silva-Pavez E, Hidalgo-Fadic Y and Ahumada-Castro U (2026) GLP-1 receptor and Mitochondria-ER Contact Sites: an emerging mechanism of metabolic regulation
GLP-2 acts a pleotropic regulator of intestine function via direct and indirect actions
A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class