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mtDNA polymerase gamma (POLG), encoded by nuclear DNA (nDNA), was shown to participate in the replication, synthesis, and repair of mtDNA ( Mitochondria and Epigenetic Modifications in Parkinsons Disease Multiple lines of evidence suggest that pathological processes in PD may result from a combination of both genetic and environmental factors (epigenetic modifications)

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However, in healthy resistance-trained individuals, the muscle-building effect may be modest compared to structured strength training and adequate nutrition

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