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Under hypoxic conditions, M9a+sh EPAS1 cells exhibited the highest viability, with live cell percentages increasing by 55% and 109% compared to M9a+shCTR and M7/8+shCTR cells, respectively (Fig

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In the early stages of DKD, increased hyper-reabsorption and gluconeogenesis expose proximal tubular cells to hypoxia, resulting in mitochondrial dysfunction, increased oxidative stress and tubular injury (39)