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Methods: We developed a 3D in vitro model of ALGS by generating liver organoids from human induced pluripotent stem cells (iPSC)

[PMC free article] [PubMed] [Google Scholar] 15.Stavrides J.C

This endogenous production makes glutathione a critical line of defense against oxidative stress, a harmful condition caused by an imbalance between free radicals and antioxidants in the body

As 2 agonists lack the GABAergic activity to prevent and treat DT or seizures, they can only be used as adjunctive therapy to reduce autonomic hyperactivity that cannot be controlled by BZD alone.3, 80, 86 Several studies demonstrated a BZDsparing effect with significant reduction in BZD requirement.87, 88, 89 8.3.4

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