Because GPX4 is the major PLOOH-neutralizing enzyme, one of the usual molecular mechanisms of erastin and RSL-3-induced ferroptosis is that both compounds inhibit GPX4 activity, except that erastin does so directly, whereas RSL-3 inhibits GPX4 activity by inhibiting cysteine uptake (Shintoku et al., 2017)
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Considering the rate of misdiagnosis, it may be prudent to rule out type 1 diabetes regardless of your weight or age by testing your c-peptide level or checking for autoantibodies
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doi: 10.1016/S0021-9258(19)69015-0 3 LundPKGoodmanRHMontminyMRDeePCHabenerJF
