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Conditions that shorten red cell lifespan such as haemolytic anaemia or acute blood loss mean cells spend less time in circulation and accumulate less glycated haemoglobin, producing a spuriously low HbA1c even when blood glucose is elevated

An important role of GSSG in the NFkB activating signal cascade is suggested by the fact that the potent NFkB inducer TPA increases intracellular GSSG levels and GSSG/GSH ratios

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The test does not actually detect the drug itself in most cases