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It is "lipophilic," meaning it prefers fat over water
However, case reports and observational studies have described instances where patients taking GLP-1 receptor agonists experienced severe, persistent symptoms consistent with gastroparesis
Using an SGLT2i with a drug like Telmisartan can inpact PPAR alpha and PPAR gamma, affecting everything from sympathetic overactivation to insulin resistance to mitochondrial dysfunction
