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The Medi-Cal decision underscored the tension between expanding access to effective weight management tools and managing the fiscal reality of public insurance programs

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Despite the early termination of the trial, it is interesting to note that 13 of 140 patients had a median duration of response of 10.2 months, indicating that these patients benefited from combination therapy and that exploring the mechanisms of this benefit should be the focus of future research

However, since calcium-actin binding naturally occurs at a rate much faster than normal force development, it is unlikely to be a limiting factor and, thus, a mechanism of enhanced contractile function