MOTS-c is a mitochondrial-derived peptide that activates AMPK, the same metabolic switch exercise and fasting flip, improving insulin sensitivity, mitochondrial function, and metabolic flexibility
If you have known MTHFR mutations, a history of poor response to cyanocobalamin, or strong preference for methylcobalamin, seeking a formulation with that form is reasonable
What we have is an enormous amount of anecdotal reporting, mostly from athletes and biohackers who've used it for injury recovery, combined with animal data that's mechanistically compelling
What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect
But the kind of large-scale clinical trials you depend on to know whether somethings worth it