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The best characterized of these paracrine intermediates are keratinocyte growth factor (KGF), which mediates GLP-2-induced colonic growth, and insulin-like growth factor-1 (IGF-1), which is essential for GLP-2s trophic effects in the small intestine (68)
Consequently, it has not been widely adopted as a stand-alone treatment for obesity (Table 1)
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Glu9 of the GLP-1 forms a direct hydrogen bond with Tyr152, an ionic interactions with Arg190, and a water mediated hydrogen bond with Tyr241
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