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Patients on orforglipron should be aware of gallstone symptoms (right upper quadrant pain, nausea after fatty meals) and report them promptly

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At our clinic we recommend at least 800 to 1000 calories per day to those on a GLP-1 and smaller, frequent meals where the protein intake is distributed throughout the day for example, 15 g for breakfast, 25 g at lunch, 30 g at dinner to enhance absorption, says Elisabetta Politi, RD, LDN, certified diabetes care and education specialist at the Duke Lifestyle and Weight Management Center in Durham, North Carolina

This can cause your body to make more hormones involved in inflammation, like cytokines and adipokines