These drugs are now being prescribed to millions worldwide , making them among the most impactful medical breakthroughs of the decade
The short-acting GLP-1 receptor agonists primarily lower postprandial blood glucose levels through inhibition of gastric emptying, whereas the long-acting compounds have a stronger effect on fasting glucose levels, which is mediated predominantly through their insulinotropic and glucagonostatic actions
As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis
Brands can promote their better-for-you products as smart and balanced choices for consumers on GLP-1 medications
Actively managing filler longevity over time is also very important, said Joseph