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These findings support the idea that some patients may have partial biologic resistance to incretin-based therapies, said Robert Glatter, MD, attending physician in the Department of Emergency Medicine at Lenox Hill Hospital in New York City, and Assistant Professor of Emergency Medicine at Zucker School of Medicine at Hofstra/ Northwell

This structure of the brain contains groups of neurons that increase the feeling of satiety, such as the pro-opiomelanocortin (POMC) and cocaineamphetamine-regulated transcript-containing (CART) neurons, but also those that trigger appetite and eating behaviorsneuropeptide Y (NPY) and agouti-related peptide (AgRP) (Barakat et al., 2024)

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As inflammation, autonomic tone, and detrusor overactivity all contribute to OAB, we speculate that GLP-1 RA could additionally influence bladder function