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Because DSIP is a small peptide that acts on the central nervous system and is degraded relatively quickly in plasma (for example, one study reported a half-life of ~78 minutes in human plasma)

The accumulation of excess fat leads to elevated estrogen levels and diminished testosterone levels, disrupting sperm production and quality

References ACS Chemical Biology (2023) Synthetic ERR// Agonist Induces an ERR-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity Journal of Pharmacology and Experimental Therapeutics (2024) A Synthetic ERR Agonist Alleviates Metabolic Syndrome Circulation (2024) Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function American Journal of Pathology (2023) Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

Another consideration involves the integration of these compounds within a broader research framework