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Research has shown that: Weight regain often occurs if semaglutide is discontinued, with most patients regaining two-thirds of their lost weight within a year Long-term use may be necessary for maintaining weight loss, similar to treatments for other chronic conditions Regular monitoring by healthcare providers helps identify and address any concerns Five-year safety data now becoming available continues to support the medications favorable risk-benefit profile The FDA continues post-marketing surveillance of semaglutide to identify any rare adverse events that might not have been detected in clinical trials