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It is now known to reside quiescently in the cytoplasm of virtually all cell types and to be evolutionarily conserved from Drosophila to humans

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The maximum lipolytic capacity has been shown to be reduced in adipocytes isolated from obese subjects compared with adipocytes from nonobese control subjects following stimulation with the phosphodiesterase-resistant cAMP analogue dibutyryl cAMP (65)

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